Noticias de IA - ítems

arXiv:2610.14489v2 Announce Type: replace Abstract: Reusable wearable PPG representations should capture local pulse morphology and broader physiological regularities. Existing pretraining objectives, however, usually apply supervision at the recording or pair level, overlooking that different concepts become reliable over different scopes of waveform evidence. We propose HiPPT, a physiology-grounded framework that matches each supervision source to its appropriate evidence scope. We construct a PPG-Text corpus of over 4 million wrist-worn recordings from 202K users, pairing recordings with waveform-derived morphology and metadata-derived context descriptions. HiPPT combines record-level morphology alignment, which grounds individual recordings in pulse characteristics, with cross-recording context alignment, which aggregates recordings sharing the same metadata tuple to capture context-consistent regularities. Waveform-guided text modeling further recovers masked contextual concepts from PPG patch representations, providing fine-grained waveform-text supervision. Across six downstream tasks spanning blood pressure, vascular stiffness, physiological attributes, and cross-dataset heart-rate estimation, HiPPT achieves the best result on the primary linear-probing metrics. The aligned space also supports zero-shot profiling of age group, sex, and BMI category, individually and jointly, with performance improving as more recordings are aggregated. These results show that evidence-scope matching yields transferable and semantically accessible wearable PPG representations. Code and pretrained weights will be released.

arXiv:2610.11399v3 Announce Type: replace Abstract: Many applications of language models require estimating the expectation of a test functional under the model. Obtaining precise estimates can be computationally expensive. We show how to improve estimation precision by exploiting next-token conditional probabilities available as a by-product of sampling. Our approach uses potentials: real-valued functions of prefixes that induce an additive decomposition of the test functional. We construct a family of estimators parameterized by these potentials and derive conditions for variance reduction. Across applications including entropy estimation, watermark detection, and rare-event probability estimation, our estimators achieve substantial variance reductions relative to Monte Carlo and importance sampling baselines at comparable computational cost.

arXiv:2610.10513v2 Announce Type: replace Abstract: Language-model agents are increasingly asked to carry out open-ended scientific research, yet their results are usually graded against a known answer, a rubric, or a language-model reviewer, none of which can tell whether a new scientific model is valid. The AI Science Exam for El Nino-Southern Oscillation (SciExam for ENSO) is a benchmark in which agents build low-order stochastic models of ENSO, the dominant mode of interannual climate variability, from real observations. Within a six-hour budget, agents process the observations, write their own diagnostics, which are then frozen, and develop a model using only these diagnostics as feedback. Hidden graders then test whether the model reproduces ENSO's statistics, recovers unobserved variables, and forecasts held-out years, and score a published model in the same way. Across twelve agent systems, six produce models that score higher than the published model, mainly through better reconstruction and forecasting. The simplified forms of the stronger models are each compatible with one of the two competing explanations of ENSO's warm-cold asymmetry, an open debate that the task never mentions. Controlled runs of the top system under varied information suggest that its scores do not come from recalling the dated observational record and that the information it receives shapes how it builds its model. SciExam for ENSO can thus evaluate agent research where no answer is known, and the results suggest that agents can already build competitive models whose structures bear on questions that scientists still debate.

arXiv:2610.06044v2 Announce Type: replace Abstract: Liquid-rocket thrust-chamber design involves interdependent analyses in which downstream constraints can require earlier design decisions to be revisited. Managing these dependencies across heterogeneous tools requires consistent design information and coordinated updates throughout the workflow. We present RocketAgent, a long-horizon engineering agent for multidisciplinary preliminary design of liquid-rocket thrust chambers. A single plan-owning Coding Agent coordinates engineering skills for performance sizing, subsystem optimization, geometry generation, and multiphysics assessment. A provenance-aware knowledge graph supports method selection, while a typed Design Intermediate Representation maintains shared parameters, artifacts, and decisions. Revision-aware checks invalidate affected results and block superseded inputs, with consequential changes subject to engineering approval. In a representative simulation-based design, RocketAgent continued from an infeasible cooling search through an engineer-authorized operating-point revision, identified feasible subsystem designs, and coordinated subsequent geometry generation and multiphysics assessment to support final configuration selection. Separate module tests assessed surrogate predictions and nozzle adaptation. A two-configuration comparison across three controlled scenarios verified the expected dependency invalidations and superseded-input blocking before solver execution. The representative case demonstrates sustained coordination across a multidisciplinary design workflow, while the controlled tests establish the behavior of the revision mechanisms supporting that execution.

arXiv:2610.03098v2 Announce Type: replace Abstract: Codon optimization, the process of selecting synonymous codons to improve mRNA translation efficiency and protein expression, is central to therapeutic protein production and mRNA vaccines, yet it remains a hard problem. The design space is discrete and combinatorially large, precluding gradient-based methods, and existing tools rely on heuristic proxies (e.g., Codon Adaptation Index or GC-content) that poorly capture true expression. We introduce Latent-Space Codon Optimization (LSCO), which recasts this discrete problem as a continuous one by mapping sequences into the latent space of a pretrained mRNA language model, enabling efficient gradient-based search. LSCO combines four components: a data-driven expression objective from an uncertainty-aware predictor, a Minimum-Free-Energy regularizer for structural stability, a naturalness prior from a protein-to-codon back-translation model, and constrained decoding for protein fidelity. On a real-world, wet-lab antibody expression dataset, LSCO outperforms simple frequency-based, as well as modern deep generative baselines in predicted expression, while retaining suitable biophysical properties.

arXiv:2609.34241v2 Announce Type: replace Abstract: Guard models support the safe deployment of language model agents, but fixed risk taxonomies limit their ability to accommodate requirements that vary across applications and tasks. Under user-defined policies, detecting violations requires interpreting both the applicable rules and the agent's behavior, since identical actions can receive different judgments under different policies. To support learning this capability, we introduce AdaptiveSafety, a dataset of 10,939 training examples and 1,000 test examples covering policies with 1--100 rules. The dataset combines trajectories from multiple sources with policy and behavioral counterfactuals, pairing each example with an explanation and the complete set of violated rules. These counterfactuals expose changes that alter compliance, while structural augmentations provide supervision for consistency under rule reordering and identifier remapping. Building on this supervision, we propose SafePO, a reinforcement learning algorithm for refining violation identification while balancing explanatory reasoning and final verdicts. SafePO uses structured rewards to assess prediction correctness, retains group-relative advantages at the response level, and employs a separately trained value model to modulate token weights within explanation and verdict regions. Separate normalization controls their relative contribution to training despite differences in length. Through supervised initialization followed by SafePO, we develop AdaGuard, a family of 0.6B, 4B, and 8B guard models that assess agent trajectories under policies supplied at inference time. Our 4B model achieves binary accuracies of 89.30\% on AdaptiveSafety and 71.82\% on DynaBench. The project repository is available at https://github.com/Yunhao-Feng/AdaGuard

arXiv:2609.34007v2 Announce Type: replace Abstract: Electronic health records (EHRs) encode clinical histories as (time, modality, code) tuples, whereas pretrained language models expect text tokens. Serializing tuples as text inflates sequence length and repeatedly encodes the same structure. We introduce EHRAdapt, an adapter that maps tuples directly into a frozen language model's embedding space. Modality and time gaps enter through a learned embedding and attention biases, and event codes receive dedicated vectors. Learning them is challenging because clinical vocabularies are long-tailed, leaving rare events with few observations. EHRAdapt therefore represents each event vector as the sum of a semantic prior and an evidence residual. The prior is a frozen, ontology-trained biomedical embedding of the event's clinical description, mapped into the input space by a shared learned projection, so it supplies clinical meaning even when observations are scarce. The residual is a learned low-rank, event-specific correction that refines it as evidence accumulates. We perform continued pretraining on records from about 4 million patients with three frozen LLM backbones, OLMo2 1B, Llama3.2 1B, and OLMo2 7B, training only the adapter (0.1--0.6% of all parameters). The full adapter outperforms all ablations in held-out next-event prediction on every backbone. Removing the semantic pathway hurts rare events most, over ten times more than the most frequent ones, whereas removing the residual hurts overall prediction but improves it for the rarest events. On reportable infectious-disease and syndromic classification, EHRAdapt outperforms text-based LLM and count-based baselines and the same LLMs adapted to the same records through next-event prediction, and both pathways improve rare-disease discrimination. The two pathways therefore play complementary roles, visible only when results are broken down by event frequency.

arXiv:2609.29381v2 Announce Type: replace Abstract: Complex lung cancer decisions can involve several defensible pathways whose eligibility, sequencing and safety depend on unresolved information. Effective support must make explicit how patient conditions govern pathway eligibility, deferral and redirection. MedGPT Clinical Explorer (MCE) organizes alternatives, decision-changing unknowns, safety constraints and fallback into a conditional strategy for clinician review. To evaluate this representation in physician-authored strategies, multidisciplinary experts established case-specific references for 40 cases within a purposive 100-case corpus, and 250 physicians from 98 institutions produced 2,250 strategies under unaided, retrieval-reference and MCE-assisted conditions. MCE-assisted strategies expressed more applicable clinical requirements, measured by the Admissible Pathway Attainment Score (APAS; 0-100), than unaided strategies (adjusted difference, 12.87; 95% CI, 11.18-14.55) and retrieval-reference strategies (5.22; 3.52-6.93). With the same knowledge base available in the retrieval-reference and MCE-assisted conditions, the additional content centered on candidate pathways, decision-critical information and safety constraints. Physicians' whole-strategy acceptability judgments correlated with APAS (Spearman's rho = 0.671), while a complementary relationship audit assessed whether candidates, conditions and subsequent actions were coherently connected. Together, these findings identify two complementary dimensions of open-ended decision support: coverage of clinically relevant content and coherent links among pathways, conditions and subsequent actions. MCE provides a shared decision object that makes consequential omissions and pathway contingencies visible before action; prospective studies should evaluate its effects on clinical workflow and patient outcomes.

arXiv:2609.17631v2 Announce Type: replace Abstract: AI-assisted claims can appear authoritative when evidence, analysis, human authorization, presentation, and correction history describe different states. We develop Publication Authority: an exact-state, non-transferable, single-use publication capability within PAC-2026 (Publication-Accountability Calculus), an AIJIM Protocol candidate. The evaluated specification version (SF-4) defines six non-compensating obligations: evidence, runs and artifacts, measurement disclosure, authorization, surface correspondence, and lifecycle continuity. Each yields a target-bound witness, localized counterexample, or localized unverifiability. Only a fresh, complete all-pass record derives a permit consumed by one atomic publication transition. Ten models explored 110,764 distinct safe reachable states; 76 unsafe configurations yielded the expected violation or observer countermodel. A surface passing its correspondence check cannot authorize publication unless admitted by the accepted record. SF-4 separates evidence horizon from verification time and rejects authentic but causally invalid authorization. An in-house, instance-blind study (G7-B) matched 183 scored expectations after shared integration. Three author-led native comparisons identify gaps in a constructed in-toto/OPA profile: measurement-state admission, proof-expiry evaluation, and required-run identity. Repairs restore parity on the tested cases. An exploratory extension constructs exact claim-edit regions under existing e-closure semantics: a minimum retained core qualifies every permitted selection. For the full hypothesis universe (U=H), a quadratic frontier computes all strongest-core sizes. Enumeration and native controls distinguish reusable statistical qualification from the fresh publication authority each candidate requires. Results yield transferable protection rules; independent conformance and field evaluation remain open.

arXiv:2609.09226v2 Announce Type: replace Abstract: Understanding the brain's mechanisms is crucial in neuroscience, particularly for simulating natural intelligence and advancing artificial general intelligence (AGI). Liu et al. (2024) and Deco et al. (2025) propose that quantum entanglement may underlie the synchronization of millions of neurons, introducing the Liu-Chen-Ao (LCA) hypothesis of entangled nerve fibers. However, directly testing this idea remains challenging. Here we employ a nonlocal many-body wave equation, introducing a generalized probability-wave framework to model collective behaviors among adaptive, interacting agents, particles, or neurons. This approach enables testable eigenmodes, offering an indirect means of examining the LCA hypothesis by observing patterns in collective trading behaviors. These patterns, rooted in behavioral psychology, are thought to mirror the internal brain's decision-making and underlying mechanisms. Our analysis of Chinese intraday stock market data shows that adaptive entangled game modes explain 82%-94% of decision patterns, sharply contrasting neoclassical finance predictions assuming independent rational agents. Additionally, 2-12% of actions adapt to news, events, and environmental changes, marked by rapid equilibrium shifts, while truly independent behaviors make up less than 5%. These results empirically support the LCA hypothesis and underscore the need to simulate the brain's mechanisms and generate adaptive, entangled modules for AGI. They also expose the shortcomings of conventional artificial neural networks (ANNs) that depend on vast, opaque parameters. By combining ANN-based AI with probability-wave-based entangled brain simulations, machine learning enables the creation of human-like processing units (HPUs). Such HPUs promise more efficient and robust AGI, particularly for embodied intelligence and robotics.